Tachykinin antagonist I: Specific, competitive and tissue-selective neurokinin B antagonists on contractile activity in smooth muscles.

نویسندگان

  • T Hashimoto
  • Y Uchida
  • S Naminohira
  • T Sakai
چکیده

Two neurokinin B (NKB) analogs, [Gly6]-NKB [3-10] and [Arg3, D-Ala6]-NKB [3-10], were tested for agonistic activity as well as for their ability to antagonize the myotropic actions of NKB, neurokinin A, substance P, physalaemin and eledoisin in isolated guinea-pig ileum, guinea-pig urinary bladder, rat duodenum, rat vas deferens and rat portal vein. [Gly6]-NKB [3-10] in the guinea-pig ileum and rat portal vein and [Arg3, D-Ala6]-NKB [3-10] in the guinea-pig ileum were found to be the first specific and competitive antagonists against NKB.

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Structure-Activity Study of Guinea Pig Trachea Tachykinin NK-2 Receptor: Effect of Substitution at the Seventh Position from C-Terminus of Neurokinin A

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عنوان ژورنال:
  • Japanese journal of pharmacology

دوره 45 4  شماره 

صفحات  -

تاریخ انتشار 1987